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If You Like It Then You Shoulda Put Two "RINGs" on It: Delineating the Roles of vPRC1 and cPRC1.
Molecular Cell ( IF 14.5 ) Pub Date : 2020-02-20 , DOI: 10.1016/j.molcel.2020.02.002
Evan Healy 1 , Adrian P Bracken 1
Affiliation  

To delineate the roles of variant (vPRC1) and canonical (cPRC1) Polycomb repressive complex 1, Blackledge et al. (2020) and Tamburri et al. (2020) elegantly disrupt RING1A/B catalytic activity without affecting stability of either complex and then explore the precise contribution of vPRC1-mediated H2AK119ub1 to Polycomb-mediated gene repression.

中文翻译:

如果喜欢,则应在其上放两个“环”:描绘vPRC1和cPRC1的角色。

为了描述变体(vPRC1)和规范(cPRC1)的多梳抑制复合物1的作用,Blackledge等人。(2020年)和Tamburri等人。(2020)优雅地破坏RING1A / B催化活性,而不会影响任何一种复合物的稳定性,然后探索vPRC1介导的H2AK119ub1对Polycomb介导的基因阻抑的精确贡献。
更新日期:2020-02-20
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