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Bacteriophages Isolated from Stunted Children Can Regulate Gut Bacterial Communities in an Age-Specific Manner.
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2020-02-12 , DOI: 10.1016/j.chom.2020.01.004 Mohammadali Khan Mirzaei 1 , Md Anik Ashfaq Khan 2 , Prakash Ghosh 2 , Zofia E Taranu 3 , Mariia Taguer 1 , Jinlong Ru 4 , Rajashree Chowdhury 2 , Md Mamun Kabir 5 , Li Deng 4 , Dinesh Mondal 2 , Corinne F Maurice 1
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2020-02-12 , DOI: 10.1016/j.chom.2020.01.004 Mohammadali Khan Mirzaei 1 , Md Anik Ashfaq Khan 2 , Prakash Ghosh 2 , Zofia E Taranu 3 , Mariia Taguer 1 , Jinlong Ru 4 , Rajashree Chowdhury 2 , Md Mamun Kabir 5 , Li Deng 4 , Dinesh Mondal 2 , Corinne F Maurice 1
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Stunting, a severe and multigenerational growth impairment, globally affects 22% of children under the age of 5 years. Stunted children have altered gut bacterial communities with higher proportions of Proteobacteria, a phylum with several known human pathogens. Despite the links between an altered gut microbiota and stunting, the role of bacteriophages, highly abundant bacterial viruses, is unknown. Here, we describe the gut bacterial and bacteriophage communities of Bangladeshi stunted children younger than 38 months. We show that these children harbor distinct gut bacteriophages relative to their non-stunted counterparts. In vitro, these gut bacteriophages are infectious and can regulate bacterial abundance and composition in an age-specific manner, highlighting their possible role in the pathophysiology of child stunting. Specifically, Proteobacteria from non-stunted children increased in the presence of phages from younger stunted children, suggesting that phages could contribute to the bacterial community changes observed in child stunting.
中文翻译：
从发育不良儿童中分离出的噬菌体可以以特定年龄的方式调节肠道细菌群落。
发育迟缓是一种严重的多代生长障碍，影响全球 22% 的 5 岁以下儿童。发育迟缓的儿童改变了肠道细菌群落，其中变形菌门的比例更高，变形菌门包含几种已知的人类病原体。尽管肠道微生物群改变与发育迟缓之间存在联系，但噬菌体（高度丰富的细菌病毒）的作用尚不清楚。在这里，我们描述了 38 个月以下的孟加拉国发育不良儿童的肠道细菌和噬菌体群落。我们发现，这些儿童与未发育迟缓的儿童相比，拥有独特的肠道噬菌体。在体外，这些肠道噬菌体具有传染性，可以以特定年龄的方式调节细菌丰度和组成，突出了它们在儿童发育迟缓的病理生理学中可能发挥的作用。具体来说，来自非发育迟缓儿童的变形菌在来自年幼发育迟缓儿童的噬菌体存在下增加，这表明噬菌体可能有助于在儿童发育迟缓中观察到的细菌群落变化。
更新日期：2020-02-20
中文翻译：
从发育不良儿童中分离出的噬菌体可以以特定年龄的方式调节肠道细菌群落。
发育迟缓是一种严重的多代生长障碍，影响全球 22% 的 5 岁以下儿童。发育迟缓的儿童改变了肠道细菌群落，其中变形菌门的比例更高，变形菌门包含几种已知的人类病原体。尽管肠道微生物群改变与发育迟缓之间存在联系，但噬菌体（高度丰富的细菌病毒）的作用尚不清楚。在这里，我们描述了 38 个月以下的孟加拉国发育不良儿童的肠道细菌和噬菌体群落。我们发现，这些儿童与未发育迟缓的儿童相比，拥有独特的肠道噬菌体。在体外，这些肠道噬菌体具有传染性，可以以特定年龄的方式调节细菌丰度和组成，突出了它们在儿童发育迟缓的病理生理学中可能发挥的作用。具体来说，来自非发育迟缓儿童的变形菌在来自年幼发育迟缓儿童的噬菌体存在下增加，这表明噬菌体可能有助于在儿童发育迟缓中观察到的细菌群落变化。
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