Circadian clock proteins are endogenous timing mechanisms that control the transcription of hundreds of genes. Their integral role in coordinating metabolism has led to their scrutiny in a number of diseases, including nonalcoholic fatty liver disease (NAFLD). Discoordination between central and peripheral circadian rhythms is a core feature of nearly every genetic, dietary, or environmental model of metabolic syndrome and NAFLD. Restricting feeding to a defined daily interval (time-restricted feeding) can synchronize the central and peripheral circadian rhythms, which in turn can prevent or even treat the metabolic syndrome and hepatic steatosis. Importantly, a number of proteins currently under study as drug targets in NAFLD (sterol regulatory element-binding protein [SREBP], acetyl-CoA carboxylase [ACC], peroxisome proliferator-activator receptors [PPARs], and incretins) are modulated by circadian proteins. Thus, the clock can be used to maximize the benefits and minimize the adverse effects of pharmaceutical agents for NAFLD. The circadian clock itself has the potential for use as a target for the treatment of NAFLD.

中文翻译：

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脂肪肝疾病的发病机理和治疗中的昼夜节律。

昼夜节律时钟蛋白是控制数百个基因转录的内源性计时机制。它们在协调新陈代谢中起着不可或缺的作用，从而导致了对许多疾病的检查，包括非酒精性脂肪肝疾病（NAFLD）。中枢和外周昼夜节律之间的不协调是代谢综合征和NAFLD几乎每个遗传，饮食或环境模型的核心特征。将进食限制为规定的每日间隔（限时进食）可以使中枢和外周生物节律同步，从而可以预防甚至治疗代谢综合征和肝脂肪变性。重要的是，目前正在研究许多蛋白质作为NAFLD的药物靶标（固醇调节元件结合蛋白[SREBP]，乙酰辅酶A羧化酶[ACC]，过氧化物酶体增殖物-激活物受体（PPAR）和肠降血糖素）由昼夜节律蛋白调节。因此，该时钟可以用于最大化益处并且最小化药剂对NAFLD的不利影响。昼夜节律时钟本身有潜力用作治疗NAFLD的靶标。