Melt electrowriting (MEW) has grown in popularity in biofabrication research due to its ability to fabricate complex, high-precision networks of fibres. These fibres can mimic the morphology of a natural extracellular matrix, enabling tissue analogues for transplantation or personalised drug screening. To date, MEW has employed two different collector-plate modalities for the fabrication of constructs. Flat collector plates, typical of traditional 3D printing methods, allow for the layer-by-layer fabrication of 2D structures into complex 3D structures. Alternatively, rotating mandrels can be used for the creation of tubular scaffolds. However, unlike other additive manufacturing techniques that can immediately start and stop the extrusion of material during printing, MEW instead requires a continuous flow of polymer. Consequently, conventional g-code control software packages are unsuitable. To overcome this challenge, a suite of customised pattern generation software tools have been developed to enable the design of MEW scaffolds with highly-controlled geometry, including crosshatch, gradient porosity, tubular, and patient-specific configurations. The high level of design control using this approach enables the production of scaffolds with highly adaptable mechanical properties, as well as the potential to influence biological properties for cell attachment and proliferation.

熔融电子书写（MEW）由于其能够制造复杂的高精度纤维网络而在生物制造研究中变得越来越流行。这些纤维可以模拟天然细胞外基质的形态，使组织类似物能够移植或个性化药物筛选。迄今为止，MEW已经采用了两种不同的集热板形式来构造结构。传统3D打印方法特有的扁平集电板允许将2D结构逐层制造为复杂的3D结构。或者，可将旋转心轴用于制造管状支架。但是，与其他增材制造技术不同的是，MEW需要连续不断的聚合物流动，而其他增材制造技术可以在打印过程中立即开始和停止材料的挤出。所以，传统的g代码控制软件包不适合。为了克服这一挑战，开发了一套定制的模式生成软件工具，以设计具有高度可控几何形状的MEW支架，包括交叉影线，梯度孔隙率，管状和特定于患者的配置。使用这种方法进行高水平的设计控制，可生产出具有高度适应性的机械特性的支架，以及影响细胞附着和增殖的生物学特性的潜力。和患者特定的配置。使用这种方法进行高水平的设计控制，可生产出具有高度适应性的机械特性的支架，以及影响细胞附着和增殖的生物学特性的潜力。和患者特定的配置。使用这种方法进行高水平的设计控制，可生产出具有高度适应性的机械特性的支架，以及影响细胞附着和增殖的生物学特性的潜力。