Glial cell involvement in Alzheimer's disease (AD) is multi-faceted. The role of astrocytes in AD pathology, both as a causative agent of amyloid-beta (Aβ) production as well as a casualty of dysfunction resulting from the presence of Aβ has been well-delineated. In this review, we explore the influence of oxidative stress in astrocytes and the subsequent effect on Aβ levels in the brain from a perspective of intracellular calcium homeostasis and NADPH oxidase activity. The response of astrocytes to the presence of Aβ, as well astrocytic and microglial interaction and inflammatory cytokine release is also discussed, highlighting a cyclical behaviour of these cells in contributing to AD pathogenesis.

中文翻译：

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环状淀粉样β-星形细胞活性在阿尔茨海默氏病中诱导氧化应激。

胶质细胞参与阿尔茨海默氏病（AD）是多方面的。星形胶质细胞在AD病理学中的作用，既是β-淀粉样蛋白（Aβ）产生的病原体，也由于Aβ的存在而导致功能障碍。在这篇综述中，我们从细胞内钙稳态和NADPH氧化酶活性的角度探讨了星形胶质细胞氧化应激的影响以及对脑中Aβ水平的后续影响。还讨论了星形胶质细胞对Aβ的反应，以及星形胶质细胞和小胶质细胞相互作用以及炎性细胞因子的释放，突显了这些细胞在AD发病机理中的周期性行为。