Cellular metabolism is central to T cell function and proliferation, with most of the research to date focusing on cancer and autoimmunity. Cellular metabolism is associated with a host of physiological phenomena, from epigenetic changes, to cellular function and fate. For the purpose of this review, we will discuss the metabolism of T cells relating to their differentiation and function. We will cover a variety of metabolic processes, ranging from glycolysis to amino acid metabolism. Understanding how T cell metabolism informs T cell function may be useful to understand alloimmune responses and design novel therapies to improve graft outcome.

中文翻译：

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利用免疫代谢和 T 细胞功能进行实体器官移植。


细胞代谢对于 T 细胞功能和增殖至关重要，迄今为止大多数研究都集中在癌症和自身免疫方面。细胞代谢与许多生理现象相关，从表观遗传变化到细胞功能和命运。出于本综述的目的，我们将讨论与其分化和功能相关的 T 细胞代谢。我们将涵盖从糖酵解到氨基酸代谢的各种代谢过程。了解 T 细胞代谢如何影响 T 细胞功能可能有助于了解同种免疫反应并设计新疗法以改善移植结果。