In this work, we present the synthesis and characterization of five new ruthenium compounds with general formula [Ru(L)(dppb)(bipy)]PF₆, where L = cinnamic acid derivatives, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine. The cytotoxicity of the complexes was evaluated against human breast tumor cells from the lines MCF-7, MDA-MB-231 and in human (MCF-10A) or mouse (L929) non-tumor cells. Complexes Ru(L₄)(dppb)(bipy)]PF₆ (4) (L₄ = 4-hydroxycinnamic acid) and [Ru(L₅)(dppb)(bipy)]PF₆ (5) (L₅ = 3,4-dihydroxycinnamic acid) were the most selective, presenting the highest values of selectivity indexes besides inhibited some processes related to tumor progression in vitro, such as invasion, migration, and adhesion in the MDA-MB-231 cell line. In addition, the complexes 4 and 5 were able to interact with Bovine Serum Albumin (BSA) and complex 5 showed antioxidant activity.

在这项工作中，我们介绍了五种新的通式为[Ru（L）（dppb）（bipy）] PF _6的钌化合物的合成和表征，其中L =肉桂酸衍生物，dppb = 1,4-双（二苯基膦基）丁烷和联吡啶= 2,2'-联吡啶。评价了来自MCF-7，MDA-MB-231和人（MCF-10A）或小鼠（L929）非肿瘤细胞系的复合物对人乳腺肿瘤细胞的细胞毒性。络合物的Ru（L ₄）（DPPB）（联吡啶）] PF ₆（4）（L ₄  = 4-羟基肉桂酸）和[茹（L ₅）（DPPB）（联吡啶）] PF ₆（5）（L ₅ = 3,4-二羟基肉桂酸）的选择性最高，除抑制与体外肿瘤进展相关的某些过程（例如MDA-MB-231细胞系的侵袭，迁移和粘附）外，还显示出最高的选择性指数值。另外，复合物4和5能够与牛血清白蛋白（BSA）相互作用，并且复合物5显示出抗氧化活性。