BACKGROUND Adequate sleep is crucial for normal functioning. However, most people, including middle-aged adults of reproductive age, show a marked reduction in their sleep duration. Thus, sleep is a major issue that should be addressed in health management. We investigated the effects of short-term sleep restriction on subjective parameters (sleepiness, stress, fatigue) and physiological parameters (cortisol, thyrotropin [TSH], thyroxine [T4], triiodothyronine [T3], C-reactive protein [CRP]) in middle-aged adults, the recovery of these parameters after rest, and the associations between parameters. METHODS A total of 118 healthy adults (59 men, 59 women), aged 35-44 years, and without sleep problems, were enrolled. Participants underwent a 4-h sleep restriction per day for 3 day at a hospital, and then returned to their daily lives to take four days of rest. A questionnaire and blood test were administered before and after sleep restriction, and after the recovery period, to assess subjective and physiological parameters. RESULTS After sleep restriction, sleepiness, fatigue, and stress significantly increased compared to baseline. Cortisol and TSH were elevated after sleep restriction, while T4, T3, and CRP were reduced compared to baseline. After the recovery phase, all parameters were restored to levels similar to baseline levels. Changes in each parameter were mutually associated; fatigue and sleepiness had the strongest association. CONCLUSION Our results suggest that even a short period of sleep restriction can have an adverse impact on psychological and physiological stress parameters in middle-aged adults, and that adequate rest and sleep are needed to restore them to normal levels.

中文翻译：

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睡眠限制对韩国中年成年人主观和生理变量的影响：一项干预研究。

背景技术充足的睡眠对于正常功能至关重要。但是，大多数人，包括育龄的中年成年人，其睡眠时间明显减少。因此，睡眠是健康管理中应解决的主要问题。我们调查了短期睡眠限制对主观参数（嗜睡，压力，疲劳）和生理参数（皮质醇，促甲状腺激素[TSH]，甲状腺素[T4]，三碘甲腺嘌呤[T3]，C反应蛋白[CRP]）的影响。中年成年人，休息后这些参数的恢复以及参数之间的关联。方法纳入了118名健康成年人（59名男性，59名女性），年龄在35-44岁之间，没有睡眠问题。参与者每天在医院接受为期3天的4小时睡眠限制，然后回到日常生活中休息四天。在睡眠受限前后，恢复期之后进行问卷调查和验血，以评估主观和生理参数。结果限制睡眠后，与基线相比，嗜睡，疲劳和压力明显增加。与基线相比，睡眠受限后皮质醇和TSH升高，而T4，T3和CRP降低。在恢复阶段之后，所有参数都恢复到类似于基准水平的水平。每个参数的变化是相互关联的。疲劳和嗜睡的关联最强。结论我们的结果表明，即使是短暂的睡眠限制也会对中年成年人的心理和生理压力参数产生不利影响，