Morbidly obese patients are most successfully treated with bariatric surgery. Although restrictive gastric surgery physically limits food intake, it is also suggested that eating behavior and food-reward mechanisms are affected. Therefore, eating behavior and food-reward were assessed in ten patients that underwent gastric volume reduction by endoscopic gastroplication. Patients participated in test days before and one, three and twelve months after the procedure. Weight loss, food intake, appetite, gastric emptying rate, food-reward (i.e. liking and wanting) and eating behavior were assessed. Body mass index decreased from 38.3 (37.6-42.6) to 33.9 (31.0-35.9) kg/m2 after one year. Ad libitum food intake decreased significantly after one month, but not after one year. Gastric emptying rate did not change. AUC of VAS scores for desire to eat, quantity, fullness, hunger, snacking and satiety changed after one month, but not all remained significantly changed after one year. Thirst did not change. Liking scores of food items decreased significantly in the fasted as well as the satiated state after the procedure. Wanting scores did not change. Uncontrolled eating decreased significantly after three and twelve months; emotional eating was only significantly decreased after three months. The results show that food intake decreases, while VAS scores for appetite and eating behavior change accordingly. Liking, but not wanting of food items changed to benefit the weight losing patient. The effects were stronger at one-month follow-up than at 12 months, which may be a risk of relapse after initial successful weight loss. The effects of new bariatric procedures on food-reward should be studied in future randomized trials to further elucidate their impact. REGISTERED AT CLINICALTRIALS. GOV: NCT02381340.

中文翻译：

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内窥镜胃折叠术减少食物奖励的初步证据

病态肥胖患者通过减肥手术最成功。虽然限制性胃手术在物理上限制了食物摄入，但也表明饮食行为和食物奖励机制受到影响。因此，对 10 名通过内窥镜胃折叠术进行胃容积缩小的患者进行了饮食行为和食物奖励评估。患者在手术前和手术后的第 1、3 和 12 个月参加了测试。评估体重减轻、食物摄入、食欲、胃排空率、食物奖励（即喜欢和想要）和饮食行为。一年后体重指数从 38.3 (37.6-42.6) 下降到 33.9 (31.0-35.9) kg/m2。一个月后随意进食的食物摄入量显着减少，但一年后则没有。胃排空率没有变化。进食欲望的 VAS AUC 得分，数量、饱腹感、饥饿感、吃零食和饱腹感在一个月后发生了变化，但一年后并非所有都保持显着变化。口渴没有改变。在禁食和手术后的饱腹状态下，对食物的喜好分数显着下降。想要的分数没有改变。三个月和十二个月后，不受控制的饮食显着减少；情绪化进食仅在三个月后显着减少。结果表明，食物摄入量减少，而食欲和饮食行为的 VAS 分数相应地发生变化。喜欢但不想要食物的改变使减肥患者受益。1 个月随访时的效果比 12 个月时更强，这可能是最初成功减肥后复发的风险。应在未来的随机试验中研究新的减肥程序对食物奖励的影响，以进一步阐明其影响。在临床试验中注册。政府：NCT02381340。