Long non-coding RNAs (lncRNAs) play a vital role in the progression of many human diseases. The aim of this study is to explore the relationship between lncRNA-ovarian cancer associated 1 (Lnc-OC1) and PCOS. In this study, we found that Lnc-OC1 was significantly higher in PCOS granulosa cells (GCs) compared to non-PCOS GCs. Lnc-OC1 knockdown inhibited cell viability and promoted cell apoptosis, expression of aromatase mRNA and production of estradiol in KGN cells. In PCOS mice, Lnc-OC1 promoted the serum insulin release, production of angiogenesis-related factors and IκBα phosphorylation, which could be partially restored by Lnc-OC1 shRNA. These results suggest that Lnc-OC1 plays an important part in the pathogenesis of PCOS.

中文翻译：

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Lnc-OC1的下调减弱了多囊卵巢综合征的发病机理。

长的非编码RNA（lncRNA）在许多人类疾病的进展中起着至关重要的作用。这项研究的目的是探讨lncRNA-卵巢癌相关1（Lnc-OC1）与PCOS之间的关系。在这项研究中，我们发现PCOS颗粒细胞（GCs）中的Lnc-OC1比非PCOS GCs高得多。Lnc-OC1抑制在KGN细胞中抑制细胞活力并促进细胞凋亡，芳香化酶mRNA表达和雌二醇生成。在PCOS小鼠中，Lnc-OC1促进血清胰岛素释放，血管生成相关因子的产生和IκBα磷酸化，而Lnc-OC1 shRNA可以部分恢复。这些结果表明，Lnc-OC1在PCOS的发病机理中起着重要的作用。