This article introduces the application of a novel supersaturation control (SSC) approach for the crystallization of heat‐sensitive materials. Traditional SSC implements parabolic temperature profile with slow initial cooling that maximizes growth over nucleation, however, which may also promote heat degradation. The proposed semibatch SSC fixes the crystallization temperature to a sufficiently low value to minimize thermal degradation, and manipulates the flow rate of a higher temperature feed stream to control the supersaturation. The high temperature feed is produced in a continuous dissolver before feeding, thus the solution spends considerably shorter time at high temperature than in the traditional batch cooling crystallization. This work demonstrates the effectiveness of the semibatch operation for the cooling crystallization of heat‐sensitive substances by thorough simulation study as well as experimental investigations. The experimental validation confirmed the simulation results, and both analyses revealed the superiority of semibatch SSC for the crystallization of heat‐sensitive materials.

中文翻译：

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用于热敏材料冷却结晶的新型半间歇式过饱和控制方法

本文介绍了一种新型的过饱和控制（SSC）方法在热敏材料结晶中的应用。传统的SSC通过缓慢的初始冷却来实现抛物线温度曲线，从而使成核过程中的生长最大化，但是这也可能促进热降解。所提出的半间歇式SSC将结晶温度固定在足够低的值以最小化热降解，并控制较高温度的进料流的流速以控制过饱和。高温进料在进料之前在连续的溶解器中生产，因此该溶液在高温下花费的时间比传统的分批冷却结晶要短得多。这项工作通过透彻的模拟研究和实验研究证明了半间歇操作对热敏物质冷却结晶的有效性。实验验证证实了模拟结果，并且两项分析均显示出半批SSC在热敏材料结晶方面的优越性。