Tumor heterogeneity is a large conundrum in cancer medicine, making most therapeutic interventions palliative rather than curative. Here we discuss the implications of how molecularly targeted therapies in solid malignancies that promote limited cancer cell death may in fact make tumors more heterogeneous, increase aggressive phenotypes, and thus worsen patient outcomes.

中文翻译：

---

了解肿瘤异质性的原因和后果

肿瘤异质性是癌症医学中的一个巨大难题，这使大多数治疗性干预变得姑息而不是治愈。在这里，我们讨论了在实体恶性肿瘤中分子靶向疗法如何促进有限的癌细胞死亡，实际上可能使肿瘤更加异质，增加侵袭性表型并因此使患者预后恶化。