In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma.

中文翻译：

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血液病患者强化化疗后血浆白细胞介素18水平与发热性中性粒细胞减少症的复杂病程

为了寻找发热性中性粒细胞减少症 (FN) 复杂病程的生物标志物，在 FN 开始时（第 0-3 天）在强化化疗后测量了 92 名血液病患者的血浆 IL-18。复杂病程定义为血培养阳性或感染性休克。IL-18 因背景血液恶性肿瘤而异，并与白细胞计数呈负相关。在整个研究组中，IL-18 与 FN 的复杂病程无关，定义为血培养阳性或感染性休克，但在自体干细胞移植受者亚组 FN 发病后的第 1 天和第 2 天观察到相关性与非霍奇金淋巴瘤。