Mesenchymal stem cells (MSCs) are a unique population of adult stem cells that can differentiate into many cell types. As such, MSCs represent an interesting source of stem cells for use in the clinical treatment of a variety of disorders involving tissue regeneration. It is therefore crucial to investigate further, whether MSCs from patients with bone or cartilage diseases are able to provide iPSCs lines with efficient differentiation ability into MSC derivatives. For this purpose, we derived 3 stable iPSC lines from the MSCs of 3 elderly patients with osteoarthritis (OA) able to re-differentiate into MSC to make bone, cartilage and adipose tissue.

间充质干细胞（MSCs）是成年干细胞的独特群体，可以分化为多种细胞类型。这样，MSC代表了干细胞的有趣来源，用于临床治疗涉及组织再生的多种疾病。因此，至关重要的是，进一步研究来自骨或软骨疾病患者的MSC是否能够为iPSCs系提供有效分化为MSC衍生物的能力。为此，我们从3名老年骨关节炎（OA）患者的MSC中获得了3条稳定的iPSC系，它们能够重新分化为MSC，以制造骨骼，软骨和脂肪组织。