AIMS This study was conducted to evaluate existing burden and unmet needs related to mealtime insulin (MTI) injection timing among adult Japanese patients with type 1 (T1D) and type 2 (T2D) diabetes. It also aimed to evaluate if a novel MTI could reduce this burden. METHODS This study comprised of a qualitative pilot study facilitating development of an online survey; followed by an online quantitative survey involving T1D, young T2D (yT2D) and elderly T2D (eT2D) patients to assess burden of current MTI timings in Japan. RESULTS Overall, 38% patients (amongst T1D, yT2D and eT2D groups) reported injecting MTI just before start or during meal in the past month. Experiencing lower glucose level/hypoglycemic condition before the meal and forgetting were the main reasons for injecting during/after meal in T1D and T2D patients respectively. Patients reported moderate-to-severe burden in multiple aspects of their lives, associated with current MTI timing. Most patients perceived that this burden would remain the same if a faster acting MTI was available. CONCLUSIONS Substantial burden reported by Japanese patients regarding the current MTI timings suggests the need for new MTI products that could achieve optimal post-prandial glucose control at different timings to meet patients' needs in Japan.

中文翻译：

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MINUTES-J研究对日本1型和2型糖尿病患者进行了横断面调查，以了解进餐时胰岛素未满足的需求。

目的本研究旨在评估日本成年1型（T1D）和2型（T2D）糖尿病患者中与进餐时胰岛素（MTI）注射时机相关的现有负担和未满足的需求。它还旨在评估新型MTI是否可以减轻这种负担。方法：本研究包括定性的初步研究，以促进在线调查的发展。随后进行的在线定量调查涉及T1D，年轻T2D（yT2D）和老年T2D（eT2D）患者，以评估日本当前MTI时间的负担。结果总体上，有38％的患者（在T1D，yT2D和eT2D组中）在上个月开始进餐之前或进餐期间报告了MTI注射。进餐前和进餐后，进餐后，进餐后和进餐后注射葡萄糖水平较低/降血糖的情况并遗忘是主要原因。患者报告了他们生活中多个方面的中度至重度负担，与当前的MTI时间有关。大多数患者认为，如果有更快反应的MTI，那么这种负担将保持不变。结论日本患者报告的有关当前MTI时机的重大负担表明，需要能够在不同时机实现最佳餐后血糖控制以满足日本患者需求的新型MTI产品。