Several signaling pathways and basic metabolites are responsible for the control of metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism, the abnormal activities of these pathways are of the most noticeable events in cancer. This altered metabolism expedites the survival and proliferation of cancer cells, which have attracted a substantial amount of interest in cancer metabolism. Nowadays, targeting metabolism and cross-linked signaling pathways in cancer has been a hot topic to investigate novel drugs against cancer. Despite the efficiency of conventional drugs in cancer therapy, their associated toxicity, resistance, and high-cost cause limitations in their application. Besides, considering the numerous signaling pathways cross-linked with cancer metabolism, discovery, and development of multi-targeted and safe natural compounds has been a high priority. Natural secondary metabolites have exhibited promising anticancer effects by targeting dysregulated signaling pathways linked to cancer metabolism. The present review reveals the metabolism and cross-linked dysregulated signaling pathways in cancer. The promising therapeutic targets in cancer, as well as the critical role of natural secondary metabolites for significant anticancer enhancements, have also been highlighted to find novel/potential therapeutic agents for cancer treatment.

几种信号通路和基本代谢物负责控制正常细胞和癌细胞的代谢。作为癌症代谢的新兴标志，这些途径的异常活动是癌症中最引人注目的事件。这种改变的代谢加速了癌细胞的存活和增殖，这引起了人们对癌症代谢的极大兴趣。如今，靶向癌症中的代谢和交联信号通路已成为研究抗癌新药的热门话题。尽管常规药物在癌症治疗中的效率很高，但其相关的毒性、耐药性和高成本导致其应用受到限制。此外，考虑到与癌症代谢交联的众多信号通路，发现，开发多靶点和安全的天然化合物一直是当务之急。天然次生代谢物通过靶向与癌症代谢相关的失调信号通路表现出有希望的抗癌作用。本综述揭示了癌症中的代谢和交联失调的信号通路。癌症中的有希望的治疗靶点，以及天然次级代谢物对显着增强抗癌作用的关键作用，也被强调以寻找用于癌症治疗的新型/潜在治疗剂。本综述揭示了癌症中的代谢和交联失调的信号通路。癌症中的有希望的治疗靶点，以及天然次级代谢物对显着增强抗癌作用的关键作用，也被强调以寻找用于癌症治疗的新型/潜在治疗剂。本综述揭示了癌症中的代谢和交联失调的信号通路。癌症中的有希望的治疗靶点，以及天然次级代谢物对显着增强抗癌作用的关键作用，也被强调以寻找用于癌症治疗的新型/潜在治疗剂。