We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS component with dynamic and diverse roles emerging in parallel with the developing CNS. This review examines the current understanding about early CSF and its maturation and roles during CNS development and discusses open questions in the field. We focus on developmental changes in the ventricular system and CSF sources (including neural progenitors and choroid plexus). We also discuss concepts related to the development of fluid dynamics including flow, perivascular transport, drainage, and barriers.

中文翻译：

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脑脊液系统的出现和发展作用。

我们总结了最近的工作，阐明了脑脊液（CSF）如何调节脑功能。CSF不仅是用于废物的保护性流体缓冲垫和水槽，还是不可或缺的CNS组件，与不断发展的CNS并行出现的动态和多样化作用。本文回顾了当前对早期脑脊液及其在中枢神经系统发展中的成熟度和作用的理解，并讨论了该领域的开放性问题。我们专注于心室系统和脑脊液来源（包括神经祖细胞和脉络丛）的发育变化。我们还将讨论与流体动力学发展有关的概念，包括流动，血管周运输，引流和屏障。