Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers.,Developmental Cell

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Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers.
Developmental Cell ( IF 10.7 ) Pub Date : 2020-02-11 , DOI: 10.1016/j.devcel.2020.01.017
Lara Barrio ₁ , Marco Milán ₂

Affiliation

The Drosophila wing has served as a paradigm to mechanistically characterize the role of morphogens in patterning and growth. Wingless (Wg) and Decapentaplegic (Dpp) are expressed in two orthogonal signaling centers, and their gradients organize patterning by regulating the expression of well-defined target genes. By contrast, graded activity of these morphogens is not an absolute requirement for wing growth. Despite their permissive role in regulating growth, here we show that Wg and Dpp are utilized in a non-interchangeable manner by the two existing orthogonal signaling centers to promote preferential growth along the two different axes of the developing wing. Our data indicate that these morphogens promote anisotropic growth by making use of distinct and non-interchangeable molecular mechanisms. Whereas Dpp drives growth along the anterior-posterior axis by maintaining Brinker levels below a growth-repressing threshold, Wg exerts its action along the proximal-distal axis through a double repression mechanism involving T cell factor (TCF).

中文翻译：

两个正交信号中心对各向异性组织生长的调节。

果蝇的翅膀已成为机械表征形态发生剂在模式和生长中的作用的范例。无翅（Wg）和十足瘫痪（Dpp）在两个正交信号传导中心表达，它们的梯度通过调节明确定义的靶基因的表达来组织模式。相比之下，这些形态发生子的分级活性并不是机翼生长的绝对要求。尽管它们在调节生长中起了放任性的作用，但在这里我们显示Wg和Dpp被两个现有的正交信号中心以不可互换的方式利用，以促进沿发育中翼的两个不同轴的优先生长。我们的数据表明，这些形态发生子通过利用独特且不可互换的分子机制来促进各向异性的生长。

更新日期：2020-02-20

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