The Michael addition reaction is one of the most classical reactions in organic synthesis as it is widely applied to synthesis of C-X (XC,=O, N, S) bonds to produce natural compounds, and drugs. It covers a nucleophilic addition to α, β-unsaturated carbonyl compound using a carbanion or another nucleophile and deals with larger class of conjugate additions. In this review, we have explored different important Michael acceptors such as nitroolefins, α, β-unsaturated carbonyl compounds, imides, etc. for asymmetric organocatalytic Michael reactions. It covers reports on organocatalysts based on ferrocene, amine, pyrrolidine, etc. and heterogeneous catalysts based on metal oxides with all pros and cons. Future scope is also delineated.

迈克尔加成反应是有机合成中最经典的反应之一，因为它广泛用于合成CX（XC，= O，N，S）键以生成天然化合物和药物。它涵盖了使用碳负离子或其他亲核试剂向α，β-不饱和羰基化合物的亲核加成反应，并处理了更大种类的共轭加成反应。在这篇综述中，我们探索了用于不对称有机催化迈克尔反应的不同重要的迈克尔受体，例如硝基烯烃，α，β-不饱和羰基化合物，酰亚胺等。它涵盖了有关基于二茂铁，胺，吡咯烷等的有机催化剂以及基于金属氧化物的非均相催化剂的报道，各有利弊。还描述了将来的范围。