Solid acid catalysts were successfully prepared using mesoporous silica (MESOSI) as support and tungstophosphoric acid (KTPA) as active phase, which was incorporated by impregnation (MESOSI#KTPA) and inclusion ([email protected]). TEM (transmission electron microscopy) images of MESOSI samples revealed the presence of mesopores (worm-like structured) and well-defined pore channels. XRD patterns of MESOSI#KTPA samples showed small crystals of H₃PW₁₂O₄₀·6H₂O that were not present in the [email protected] materials. The specific surface area of the MESOSI modified with KTPA decreases with the increment of the heteropolyacid content. ³¹P NMR and FT-IR characterizations confirmed the existence of undegraded [H_3-XPW₁₂O₄₀]^X− and [PW₁₂O₄₀]³⁻ anions interacting with the SiOH₂⁺ groups of MESOSI. Potentiometric titration results showed that both acid strength and number of acid sites increased with the KTPA loading in [email protected] and [email protected] samples. Moreover, the acidic properties of MESOSI#KTPA materials were remarkably higher than those of [email protected] The catalysts prepared were highly active, selective and reusable in the solvent-free synthesis of 3H-1,5-benzodiazepine from 1,2-phenylenediamine and 1,3-diphenyl-1,3-propanedione.

使用介孔二氧化硅（MESOSI）作为载体和钨磷酸（KTPA）作为活性相，成功制备了固体酸催化剂，并通过浸渍（MESOSI＃KTPA）和包合物掺入（[电子邮件保护]）。MESOSI样品的TEM（透射电子显微镜）图像显示存在中孔（蠕虫状结构）和定义明确的孔道。MESOSI＃KTPA样品的XRD图谱显示H ₃ PW ₁₂ O ₄₀ ·6H ₂ O的小晶体，这些晶体不存在于[电子邮件保护的]材料中。KTPA改性的MESOSI的比表面积随杂多酸含量的增加而降低。³¹ P NMR和FT-IR表征证实存在未降解的[H_3-X PW ₁₂ ö ₄₀ ] ^X-和[PW ₁₂ ø ₄₀ ] ^3-的阴离子与所述相互作用的硅OH ₂ ⁺基团MESOSI的。电位滴定结果表明，在[受电子邮件保护的]和[受电子邮件保护的]样品中，酸强度和酸性位点的数量均随KTPA含量的增加而增加。而且，MESOSI＃KTPA材料的酸性比[email protected]的要高得多。所制备的催化剂具有很高的活性，选择性和可重用性，可以无溶剂地由1,2-苯二胺合成3H-1,5-苯并二氮杂pine和1，3-二苯基-1，3-丙二酮。