Abstract The design and development of tumor microenvironment (TME)-responsive intelligent nanoplatforms have attracted increasing interest to enhance the therapeutic effects of drugs, due to their potential to address some significant therapeutic issues, such as unsatisfying therapeutic outcomes and serious side effects. In this review, we mainly summarize the strategies used to construct these nanoplatforms based on characteristic factors present at high levels in the TME, including acidic pH values, endogenous H2O2, over-expressed enzymes, hypoxia-induced by insufficient oxygen supply, excess level of GSH, and other factors. These nanoplatforms that utilize the enhanced permeability and retention (EPR) effect and TME-triggered drug delivery enhance the therapeutic outcomes, minimize the side effects, and achieve image-guided therapy. Furthermore, the limitations and prospects of these nanoplatforms for enhanced cancer therapy are also discussed.

中文翻译：

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用于癌症治疗的肿瘤微环境响应智能纳米平台

摘要 肿瘤微环境（TME）响应智能纳米平台的设计和开发引起了人们越来越多的关注，以提高药物的治疗效果，因为它们有可能解决一些重要的治疗问题，例如治疗效果不令人满意和严重的副作用。在这篇综述中，我们主要总结了基于 TME 中高水平存在的特征因素构建这些纳米平台的策略，包括酸性 pH 值、内源性 H2O2、过度表达的酶、供氧不足引起的缺氧、过量的GSH等因素。这些利用增强渗透性和保留 (EPR) 效应和 TME 触发药物递送的纳米平台增强了治疗效果，最大限度地减少了副作用，并实现了图像引导治疗。