Cancer is one of the main causes of mortality and morbidity worldwide. However, its early non-invasive detection via quantification of appropriate biomarkers can significantly reduce mortality, enhance survival, and save treatment costs. Lateral flow test strips (LFTS) are nowadays considered as the most attractive point-of-care devices for healthcare applications. However, the quantification of cancer biomarkers in body fluids suffers from some challenges including i) the necessity for multiplex analysis, ii) the development of sensitive detection systems, iii) to overcome the analysis of complex samples, at the same time, it should keep the quality assurance criteria for an accurate and proper diagnostic. This review provides an overview of recent advances, the current challenges and available solutions in cancer biomarkers detection via LFTS focusing on the sensitivity enhancement by various detection systems. Then, the available LFTS kits in the market are presented and future trends in this area are foreseen.

癌症是全世界死亡率和发病率的主要原因之一。但是，通过对适当生物标记物进行定量的早期非侵入式检测可以显着降低死亡率，提高生存率并节省治疗费用。如今，侧向流动测试条（LFTS）被认为是医疗保健应用中最有吸引力的即时护理设备。然而，体液中癌症生物标志物的定量分析面临一些挑战，包括：i）进行多重分析的必要性，ii）开发灵敏的检测系统，iii）克服复杂样品的分析，同时，应保持准确，正确诊断的质量保证标准。这篇评论概述了最近的进展，通过LFTS检测癌症生物标志物的当前挑战和可用解决方案侧重于通过各种检测系统提高灵敏度。然后，介绍了市场上可用的LFTS套件，并预测了该领域的未来趋势。