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Encapsulation and release of drug nanoparticles in functional polymeric vesicles
Soft Matter ( IF 2.9 ) Pub Date : 2020/02/20 , DOI: 10.1039/d0sm00069h Lei Jia 1, 2, 3, 4, 5 , Rong Wang 1, 2, 3, 4, 5 , Yining Fan 4, 5, 6, 7, 8
Soft Matter ( IF 2.9 ) Pub Date : 2020/02/20 , DOI: 10.1039/d0sm00069h Lei Jia 1, 2, 3, 4, 5 , Rong Wang 1, 2, 3, 4, 5 , Yining Fan 4, 5, 6, 7, 8
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We investigated the co-assembly of amphiphilic diblock copolymers in solutions containing drugs and functional nanoparticles using the dissipative particle dynamics (DPD) method. By controlling the size and the concentration of the functional nanoparticles, the length of the hydrophobic blocks, and the interaction parameters between the hydrophobic block/solvent and the functional nanoparticles, we obtained the desired aggregates to load drugs. The aggregates loaded with drugs can be disk-like micelles, sphere-like micelles and vesicles with functional nanoparticles on the surface. When the solvent environment changes, the drugs loaded in the functional vesicles can release into the solvent. The release content is critically dependent on the repulsive interaction between the drugs and the solvent. The dynamic curve of drug release is obtained. The result is in agreement with the experiments about drug release. Our studies showed that we can precisely control the formation of functional vesicles to load and release drugs. Loading drugs in the process of self-assembly and controlling the release have broad potential in the field of clinical medicine and adding functional nanoparticles can be of great help in drug delivery and medical diagnosis.
中文翻译：
功能性聚合物囊泡中药物纳米颗粒的包封和释放
我们使用耗散粒子动力学（DPD）方法研究了两亲性二嵌段共聚物在含有药物和功能纳米粒子的溶液中的共组装。通过控制功能性纳米颗粒的大小和浓度，疏水性嵌段的长度以及疏水性嵌段/溶剂与功能性纳米颗粒之间的相互作用参数，我们获得了所需的聚集体以加载药物。载有药物的聚集体可以是盘状的胶束，球形的胶束和表面具有功能性纳米颗粒的囊泡。当溶剂环境发生变化时，功能性囊泡中加载的药物会释放到溶剂中。释放量主要取决于药物与溶剂之间的排斥相互作用。获得药物释放的动态曲线。结果与关于药物释放的实验一致。我们的研究表明，我们可以精确控制功能性囊泡的形成，以上载和释放药物。在自组装过程中加载药物和控制释放在临床医学领域具有广阔的潜力，而添加功能性纳米颗粒可以在药物输送和医学诊断中起到很大的帮助。
更新日期：2020-03-26
中文翻译：
功能性聚合物囊泡中药物纳米颗粒的包封和释放
我们使用耗散粒子动力学（DPD）方法研究了两亲性二嵌段共聚物在含有药物和功能纳米粒子的溶液中的共组装。通过控制功能性纳米颗粒的大小和浓度，疏水性嵌段的长度以及疏水性嵌段/溶剂与功能性纳米颗粒之间的相互作用参数，我们获得了所需的聚集体以加载药物。载有药物的聚集体可以是盘状的胶束，球形的胶束和表面具有功能性纳米颗粒的囊泡。当溶剂环境发生变化时，功能性囊泡中加载的药物会释放到溶剂中。释放量主要取决于药物与溶剂之间的排斥相互作用。获得药物释放的动态曲线。结果与关于药物释放的实验一致。我们的研究表明，我们可以精确控制功能性囊泡的形成，以上载和释放药物。在自组装过程中加载药物和控制释放在临床医学领域具有广阔的潜力，而添加功能性纳米颗粒可以在药物输送和医学诊断中起到很大的帮助。
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