Dietary antioxidant intake has been hypothesised to influence lung function. The association between total antioxidant capacity (TAC) of the diet at age 8 years and lung function development up to 16 years in 2307 participants from the Swedish population-based birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology) was investigated. Information on TAC was obtained from a food frequency questionnaire at 8 years. Lung function was measured by spirometry at 8 and 16 years, impulse oscillometry (IOS) and exhaled nitric oxide fraction (FeNO) at 16 years. Low lung function was defined as forced expiratory volume in 1 s (FEV1) z-score below the 25th percentile. Longitudinal associations between TAC and lung function were analysed by mixed effect models adjusted for potential confounders. Stratification by asthma at 8 years was performed to examine effect modification. The median TAC intake was 10 067 μmol Trolox equivalents (TE)·g−1, with males having a lower mean compared to females (9963 versus 10 819 μmol TE·g−1). In analyses of lung function change between 8 and 16 years, there were no statistically significant associations between TAC in tertiles and spirometry results for the total study population. Among children with asthma at 8 years (prevalence 7%), higher TAC was associated with higher mean FEV1 (0.46 sd, 95% CI 0.11–0.80) and decreased odds of low lung function at 16 years (OR 0.28, 95% CI 0.12–0.65). There were no associations between TAC and forced vital capacity or IOS/FeNO results. High dietary antioxidant intake in school age may be associated with improved lung function development from school age to adolescence among children with asthma. Dietary antioxidant intake at school age may influence lung function development as measured by FEV1 up to adolescence among children with asthma. In contrast, no association was observed among children without asthma. http://bit.ly/2CzEZ8W

中文翻译：

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学龄期膳食抗氧化剂摄入量和肺功能发育直至青春期

已经假设膳食抗氧化剂摄入量会影响肺功能。研究了来自瑞典人口出生队列 BAMSE（儿童、过敏、环境、斯德哥尔摩、流行病学）的 2307 名参与者在 8 岁时饮食的总抗氧化能力 (TAC) 与肺功能发育长达 16 年之间的关联。关于 TAC 的信息是从 8 岁时的食物频率问卷中获得的。肺功能通过 8 岁和 16 岁的肺活量测定法、脉冲示波法 (IOS) 和 16 岁的呼出一氧化氮分数 (FeNO) 测量。低肺功能定义为 1 秒内用力呼气量 (FEV1) z 值低于 25%。通过针对潜在混杂因素调整的混合效应模型分析 TAC 与肺功能之间的纵向关联。在 8 年时进行哮喘分层以检查效果改变。中位 TAC 摄入量为 10 067 μmol Trolox 当量 (TE)·g-1，男性的平均值低于女性（9963 对 10 819 μmol TE·g-1）。在对 8 至 16 年间肺功能变化的分析中，三分位数中的 TAC 与整个研究人群的肺活量测定结果之间没有统计学上的显着关联。在 8 岁哮喘儿童（患病率 7%）中，较高的 TAC 与较高的平均 FEV1（0.46 sd，95% CI 0.11-0.80）和降低的 16 岁低肺功能几率相关（OR 0.28，95% CI 0.12 –0.65）。TAC 与用力肺活量或 IOS/FeNO 结果之间没有关联。学龄期高膳食抗氧化剂摄入量可能与哮喘儿童从学龄期到青春期的肺功能发育改善有关。学龄期膳食抗氧化剂摄入量可能会影响哮喘儿童的肺功能发育（通过 FEV1 测量直至青春期）。相反，在没有哮喘的儿童中没有观察到相关性。http://bit.ly/2CzEZ8W