Most previous epidemiological studies support a significant association between marijuana smoking and chronic respiratory symptoms [1], but the effects on lung function remain unclear. Previous longitudinal cohort studies have focused largely on young adults [1]. The results from these studies have shown that marijuana smoking produced marginal or no effects on lung function, which is expected given that with even heavy cigarette exposure, meaningful changes in forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) are hard to discern in young adults. Lung function changes, however, accelerate in older age groups and the impact of respiratory irritants and toxins on lung function becomes much more evident [2]. To our knowledge, our study is the first longitudinal study of marijuana smoking in older individuals in a general population whose median age was 65 years [3]. The results of the present study addressed a major gap in marijuana research by demonstrating that marijuana smoking amplifies the harmful effects of tobacco smoking on the risk of COPD and FEV1 decline over time. Marijuana smoke exposure amplifies the harmful effects of cigarette smoke http://bit.ly/2rS6mtt

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吸食大麻对老年人肺功能的影响

大多数先前的流行病学研究支持吸食大麻与慢性呼吸道症状之间存在显着关联 [1]，但对肺功能的影响仍不清楚。以前的纵向队列研究主要关注年轻人[1]。这些研究的结果表明，吸食大麻对肺功能的影响很小或没有影响，这是预期的，因为即使大量接触香烟，1 秒内用力呼气量 (FEV1) 或用力肺活量 (FVC) 的有意义的变化是在年轻人中很难辨别。然而，肺功能变化在老年人群中加速，呼吸道刺激物和毒素对肺功能的影响变得更加明显 [2]。据我们所知，我们的研究是第一项针对中位年龄为 65 岁的一般人群中老年人吸食大麻的纵向研究 [3]。本研究的结果表明，吸食大麻会放大吸烟对 COPD 风险和 FEV1 下降的有害影响，从而解决了大麻研究中的一个重大空白。接触大麻烟雾会放大香烟烟雾的有害影响 http://bit.ly/2rS6mtt