Abstract

Silk fibroin (SF) aqueous solution was obtained by the degumming and dissolution of tussah silk, and then the obtained solution was chemically cross-linked with sodium alginate (SA) to form composite membrane, which could be used as a carrier for sustained drug release. The mechanical properties and dissolution rate of such composite membrane together with the drug release behavior under different conditions were investigated. A series of structure-tunable composite membranes were prepared through altering the ingredients proportion, the pH value during fabrication, the concentration of Ca²⁺, and cross-linking time. The drug release behavior of the corresponding drug-loaded composite membrane was elaborate studied using artemisinin as the model drug. It was found that the drug release rate exhibited a decreasing trend with increasing the SF content, the Ca²⁺ concentration and the cross-linking time of the corresponding composite membrane. Moreover, the drug release behavior exhibited pH sensitivity, and the drug release rate could be promoted under weak alkaline conditions.

中文翻译：

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s蚕丝素蛋白复合膜的制备及释药性能

摘要

通过对蚕丝进行脱胶和溶解得到丝素蛋白（SF）水溶液，然后将所得溶液与海藻酸钠（SA）化学交联形成复合膜，可作为药物持续释放的载体。研究了这种复合膜在不同条件下的力学性能和溶解速率以及药物的释放行为。通过改变成分比例，制备过程中的pH值，Ca ²⁺的浓度，制备了一系列结构可调的复合膜。，以及交联时间。以青蒿素为模型药物，对相应载药复合膜的释药行为进行了详细研究。结果发现，随着相应复合膜SF含量，Ca ²⁺浓度和交联时间的增加，药物释放速率呈下降趋势。而且，药物释放行为表现出pH敏感性，并且在弱碱性条件下可以促进药物释放速率。