Asymmetric access to α-hydroxy-1,4-diketones has been achieved by direct ene coupling of silyl enol ethers with glyoxal electrophiles, mediated by a chiral N,N′-dioxide–nickel(II) complex catalyst. Successful union of a polyketide silyl enol ether with an α-quaternary glyoxal, generated by dioxirane oxidation of an α-diazo ketone, models a proposed C5–C6 disconnection of the polyketide and spirocyclic imine domains of the marine natural product, portimine.

中文翻译：

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直接制备α-羟基1,4-二酮作为天然产物合成中间体的催化不对称烯反应

通过甲硅烷基烯醇醚与乙二醛亲电试剂的直接烯偶联，在手性 N,N'-二氧化物-镍 (II) 络合物催化剂的介导下，实现了对 α-羟基-1,4-二酮的不对称访问。聚酮甲硅烷基烯醇醚与 α-季戊二醛的成功结合，由 α-重氮酮的二环氧乙烷氧化生成，模拟了海洋天然产物 portimine 的聚酮和螺环亚胺域的 C5-C6 断开连接。