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The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-02-20 , DOI: 10.1038/s41372-020-0622-4
Yulia Vaisbourd 1 , Dawod Sharif 2 , Arieh Riskin 1 , Liat Yaniv 2 , Gil Dinur 3 , Khalil Amen 2 , David Bader 1 , Amir Kugelman 3
Affiliation  

OBJECTIVE To compare coronary flows between premature infants with and without hemodynamically significant patent ductus arteriosus (hsPDA) and to determine if coronary flow is influenced by medical PDA treatment. DESIGN Prospective, observational pilot study. Forty-three infants <32 weeks gestation underwent echocardiography when routinely indicated. Study group included infants with hsPDA requiring treatment. Comparison groups included infants with nonsignificant PDA and infants without PDA. RESULTS The study group (n = 13), compared with the comparison groups with nonsignificant PDA (n = 12) and without PDA (n = 18) had higher troponin levels (p = 0.003 and 0.004, respectively). In infants with hsPDA compared with infants with no PDA there was a significant increase in myocardial oxygen demand and decrease in left main coronary artery flow, with nonsignificant increase in cardiac output. CONCLUSIONS Decrease in coronary artery flows and higher troponin values may suggest a "steal effect," not allowing to meet the elevated myocardial oxygen demand in infants with hsPDA.

中文翻译:

动脉导管未闭对早产儿冠状动脉血流的影响:一项前瞻性观察性试验研究。

目的 比较具有和不具有明显血流动力学意义的动脉导管未闭 (hsPDA) 的早产儿之间的冠状动脉血流,并确定冠状动脉血流是否受医疗 PDA 治疗的影响。设计 前瞻性、观察性试点研究。43 名小于 32 周妊娠的婴儿在常规指征时接受了超声心动图检查。研究组包括需要治疗的 hsPDA 婴儿。比较组包括具有非显着 PDA 的婴儿和没有 PDA 的婴儿。结果 研究组 (n = 13) 与非显着 PDA (n = 12) 和无 PDA (n = 18) 的对照组相比,肌钙蛋白水平较高(分别为 p = 0.003 和 0.004)。与没有 PDA 的婴儿相比,患有 hsPDA 的婴儿的心肌需氧量显着增加,左冠状动脉主干血流减少,心输出量无显着增加。结论冠状动脉血流减少和肌钙蛋白值升高可能表明存在“偷窃效应”,无法满足 hsPDA 婴儿升高的心肌需氧量。
更新日期:2020-02-20
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