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Current cannabis use and smoking cessation among treatment seeking combustible smokers.
Drug and Alcohol Dependence ( IF 3.9 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.drugalcdep.2020.107928
Andrew H Rogers 1 , Justin M Shepherd 1 , Julia D Buckner 2 , Lorra Garey 1 , Kara Manning 1 , Michael F Orr 1 , Norman B Schmidt 3 , Michael J Zvolensky 4
Affiliation  

INTRODUCTION Combustible tobacco smoking and cannabis use frequently occur together, and the use of both substances is associated with overall greater severity of tobacco and cannabis related problems. Observational work has found that cannabis use is associated with tobacco cessation failure, but research directly testing the longitudinal associations of cannabis use on tobacco cessation during smoking cessation treatment is lacking. The current study examined the impact of current cannabis use on combustible tobacco cessation outcomes. METHODS 207 daily combustible tobacco smokers (Mage = 38.24 years, SD = 14.84, 48.1 % male) were enrolled in a randomized controlled smoking cessation trial. Survival analyses and multi-level modeling were used to assess lapse and relapse behavior through 12-week follow up. The current study is a secondary data analysis. RESULTS Results of the current study suggest that cannabis use is associated with faster time to lapse (OR = 0.644, se = .188, p =  .019), but not relapse (OR = -0.218, se = .403, p =  .525), compared to combustible tobacco-only smokers. Additionally, cannabis use was associated with lower likelihood of achieving any 7-day point prevalence abstinence during the 12 week follow up (b = 0.93, se = 0 0.24, p =  0.0001). CONCLUSIONS The current study provides novel evidence that cannabis use may be related to combustible tobacco use in terms of faster time to lapse and lower likelihood of any 7-day point prevalence abstinence following smoking cessation treatment. Developing integrated cannabis-tobacco cessation treatments is an important next step in research focused on tobacco-cannabis use.

中文翻译:

目前在寻求可燃吸烟者的治疗中使用大麻和戒烟。

引言 吸食可燃性烟草和吸食大麻经常同时发生,而这两种物质的使用与烟草和大麻相关问题的总体更严重程度有关。观察性工作发现,使用大麻与戒烟失败有关,但缺乏直接测试在戒烟治疗期间使用大麻与戒烟的纵向关联的研究。目前的研究检查了当前使用大麻对可燃性烟草戒烟结果的影响。方法 207 名每日可燃烟草吸烟者(Mage = 38.24 岁,SD = 14.84,48.1% 男性)参加了一项随机对照戒烟试验。生存分析和多层次建模用于通过 12 周的随访评估失效和复发行为。目前的研究是二次数据分析。结果 当前研究的结果表明,使用大麻与更快的消退时间相关(OR = 0.644,se = .188,p = .019),但与复发无关(OR = -0.218,se = .403,p = . 525),与仅吸食可燃烟草的吸烟者相比。此外,在 12 周的随访期间,大麻使用与实现任何 7 天流行率戒断的可能性较低有关(b = 0.93,se = 0 0.24,p = 0.0001)。结论 目前的研究提供了新的证据,表明大麻的使用可能与可燃烟草的使用有关,因为戒烟治疗后的任何 7 天流行率戒断的可能性更低。开发大麻-烟草戒烟综合治疗是重点研究烟草-大麻使用的重要下一步。结果 当前研究的结果表明,使用大麻与更快的消退时间相关(OR = 0.644,se = .188,p = .019),但与复发无关(OR = -0.218,se = .403,p = . 525),与仅吸食可燃烟草的吸烟者相比。此外,在 12 周的随访期间,大麻使用与实现任何 7 天流行率戒断的可能性较低有关(b = 0.93,se = 0 0.24,p = 0.0001)。结论 目前的研究提供了新的证据,表明大麻的使用可能与可燃烟草的使用有关,因为戒烟治疗后的任何 7 天流行率戒断的可能性更低。开发大麻-烟草戒烟综合治疗是重点研究烟草-大麻使用的重要下一步。结果 当前研究的结果表明,使用大麻与更快的消退时间相关(OR = 0.644,se = .188,p = .019),但与复发无关(OR = -0.218,se = .403,p = . 525),与仅吸食可燃烟草的吸烟者相比。此外,在 12 周的随访期间,大麻使用与实现任何 7 天流行率戒断的可能性较低有关(b = 0.93,se = 0 0.24,p = 0.0001)。结论 目前的研究提供了新的证据,表明大麻的使用可能与可燃烟草的使用有关,因为戒烟治疗后的任何 7 天流行率戒断的可能性更低。开发大麻-烟草戒烟综合治疗是重点研究烟草-大麻使用的重要下一步。
更新日期:2020-02-20
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