BACKGROUND Young adulthood has the highest rates of alcohol use and high-risk drinking behavior. This period is also a critical neurodevelopmental stage, with neural insults having a profound neurotoxic effect on the brain. Cortical gyrification is thought, in part, to reflect early brain maturation (e.g., hypogyrification in fetal alcohol syndrome). There is also evidence that cortical gyrification is sensitive to later-life events (e.g., fluctuations in malnutrition in young adults). However, no study has examined how alcohol use in young adulthood is associated with cortical gyrification. METHODS We examined the associations between cortical gyrification with lifetime alcohol use and past year hangover symptoms in young adults (N = 78). RESULTS Lifetime alcohol use was associated with hypogyria in multiple cortical regions (rs ≤ -.27, ps ≤ .0159; right orbitofrontal, right temporal pole, and left lateral occipital). Further, past year hangover symptoms were associated with hypogyria (rs ≤ -.27, ps ≤ .0034), overlapping with lifetime alcohol use (right orbitofrontal and left lateral occipital). Hangover symptoms were also uniquely associated with hypogyria of other cortical regions (rs ≤ -.30, ps ≤ .0002; right parahippocampal gyrus, left inferior temporal/parahippocampal gyrus and right anterior insula). CONCLUSIONS Thus, results suggest that young adulthood is a critical period for targeted prevention and intervention, especially for individuals exhibiting heavy alcohol consumption and high-risk drinking behavior.

中文翻译：

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与皮质回旋相关的年轻成年人饮酒。

背景技术成年年轻人具有最高的饮酒率和高危饮酒行为。这个时期也是神经发育的关键时期，神经损伤会对大脑产生深远的神经毒性作用。皮质回旋被认为部分反映了早期的大脑成熟（例如胎儿酒精综合症中的回旋过低）。也有证据表明皮层回旋对以后的事件很敏感（例如，年轻人营养不良的波动）。然而，尚无研究检查成年后饮酒与皮质回旋有何关系。方法我们研究了年轻人中终生饮酒与皮质回旋之间的联系以及去年成年人的宿醉症状（N = 78）。结果终生饮酒与多个皮质区域的尿量不足相关（rs≤-.27，ps≤。0159; 右眶额，右颞极和左侧枕骨）。此外，过去一年的宿醉症状与低尿（rs≤-.27，ps≤.0034）相关，并与终生饮酒重叠（右眶额和左枕骨）。宿醉症状还与其他皮质区域的神经功能减退相关（rs≤-.30，ps≤.0002;右海马旁回，左下颞/海马旁回和右前岛）。结论因此，结果表明，成年是有针对性的预防和干预措施的关键时期，特别是对于表现出大量饮酒和高危饮酒行为的人。与终生饮酒重叠（右眶额和左枕外侧）。宿醉症状还与其他皮质区域的神经功能减退相关（rs≤-.30，ps≤.0002;右海马旁回，左下颞/海马旁回和右前岛）。结论因此，结果表明，成年是有针对性的预防和干预措施的关键时期，特别是对于表现出大量饮酒和高危饮酒行为的人。与终生饮酒重叠（右眶额和左枕外侧）。宿醉症状还与其他皮质区域的神经功能减退相关（rs≤-.30，ps≤.0002;右海马旁回，左下颞/海马旁回和右前岛）。结论因此，结果表明，成年是有针对性的预防和干预措施的关键时期，特别是对于表现出大量饮酒和高危饮酒行为的人。