Dogs with babesiosis can present with multiple complications, including acute kidney injury (AKI). The objective of this study was to characterize AKI in dogs with babesiosis caused by Babesia rossi at presentation and after treatment. Thirty-five client-owned dogs with B. rossi infection and 10 control dogs were included in this prospective observational study. Blood and urine were collected in Babesia-infected dogs at presentation (T₀, n = 35), after 24 h (T_24h, n = 11), and after 1 month (T_1m, n = 9). The following urinary kidney injury biomarkers were assessed: urinary protein to creatinine ratio (UPC), urinary glomerular injury biomarkers (immunoglobulin G (uIgG) and C-reactive protein (uCRP)), and urinary tubular injury biomarkers (retinol-binding protein (uRBP) and neutrophil gelatinase-associated lipocalin (uNGAL)). Serum functional renal biomarkers were creatinine (sCr) and symmetric dimethylarginine (sSDMA). Post-mortem kidney biopsies were analyzed by light and transmission electron microscopy.

At T₀, all kidney injury biomarkers were significantly higher in Babesia-infected dogs compared to healthy controls (P < 0.001), while functional renal biomarkers were not significantly different (P > 0.05). At T_24h, all urinary tubular injury biomarkers and UPC decreased significantly (P < 0.01), while glomerular injury biomarkers did not (P = 0.084). At T_1m, all urinary kidney injury biomarkers decreased to values not significantly different from healthy controls (P > 0.5). Significant changes in functional renal biomarkers were not seen after treatment (P > 0.05). Dogs with complicated babesiosis had significantly higher glomerular injury biomarkers, UPC, and sSDMA compared to uncomplicated cases (P < 0.05), while all tubular injury biomarkers and sCr were not significantly different (P > 0.1).

Dogs with babesiosis caused by B. rossi showed transient kidney injury, which was detected by all kidney injury biomarkers, but remained undetected by functional biomarkers. All infected dogs, irrespective of disease severity, suffered comparable kidney injury based on tubular injury biomarker concentrations, while loss of function was seen more often in dogs with complicated babesiosis based on sSDMA results.

巴贝病的狗可能会出现多种并发症，包括急性肾损伤（AKI）。这项研究的目的是与巴贝斯虫病的狗引起的表征AKI巴贝罗西的表现和治疗。在这项前瞻性观察研究中纳入了35例罗氏杆菌感染的客户拥有的狗和10例对照狗。在出现时（T ₀，n = 35），24小时（T _24h，n = 11）和1个月后（T _1m），在感染巴贝虫的狗中收集血液和尿液，n = 9）。评估了以下尿路肾脏损伤生物标志物：尿蛋白与肌酐比（UPC），尿路肾小球损伤生物标志物（免疫球蛋白G（uIgG）和C反应蛋白（uCRP））和尿路肾小管损伤生物标志物（视黄醇结合蛋白（uRBP ）和中性粒细胞明胶酶相关的脂蛋白（uNGAL））。血清功能性肾脏生物标志物是肌酐（sCr）和对称二甲基精氨酸（sSDMA）。尸检后肾脏活检通过光和透射电子显微镜进行分析。

在T _0时，与健康对照组相比，巴贝虫感染的狗的所有肾脏损伤生物标志物均显着较高（P <0.001），而功能性肾脏生物标志物无显着差异（P> 0.05）。在T _24h，所有的泌尿管损伤生物标志物和UPC均显着降低（P <0.01），而肾小球损伤生物标志物没有（P = 0.084）。在T _1m，所有尿肾损伤生物标志物均降至与健康对照组无显着差异的值（P> 0.5）。治疗后未观察到功能性肾脏生物标志物的显着变化（P> 0.05）。与简单的病例相比，具有复杂性巴贝西斯病的犬的肾小球损伤生物标志物，UPC和sSDMA明显更高（P <0.05），而所有肾小管损伤生物标志物和sCr均无显着差异（P> 0.1）。

引起的巴贝斯虫病狗B.罗西表现出短暂的肾损伤，这是由所有的肾损伤生物标志物检测，但仍然被功能性生物标志物发现。根据肾小管损伤生物标志物的浓度，所有被感染的狗，无论疾病的严重程度如何，都遭受可比的肾脏损伤，而根据sSDMA结果，在患有复杂性贝氏病的狗中，更常见的是功能丧失。