CD8 T cells are among the most vigorous soldiers of the immune system that fight viral infections and cancer. CD8 T cell development, maintenance, activation and differentiation are under the tight control of multiple transcriptional and post-transcriptional networks. Over the last two decades it has become clear that non-coding RNAs (ncRNAs), which consist of microRNAs (miRNAs) and long ncRNAs (lncRNAs), have emerged as global biological regulators. While our understanding of the function of specific miRNAs has increased since the discovery of RNA interference, it is still very limited, and the field of lncRNAs is just starting to blossom. Here we will summarize our knowledge on the role of ncRNAs in CD8 T cell biology, including differentiation into memory and exhausted cells.

中文翻译：

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CD8 T 细胞生物学中的非编码 RNA。


CD8 T 细胞是免疫系统中对抗病毒感染和癌症最有力的士兵之一。 CD8 T 细胞的发育、维持、激活和分化受到多个转录和转录后网络的严格控制。在过去的二十年里，人们已经清楚地认识到，由微小RNA (miRNA) 和长链非编码RNA (lncRNA) 组成的非编码RNA (ncRNA) 已成为全球生物调节因子。虽然自从发现RNA干扰以来我们对特定miRNA功能的了解有所增加，但仍然非常有限，并且lncRNA领域才刚刚开始蓬勃发展。在这里，我们将总结关于 ncRNA 在 CD8 T 细胞生物学中的作用的知识，包括分化为记忆细胞和衰竭细胞。