OBJECTIVES This study aimed to determine vestibular involvement in patients with auditory neuropathy (AN) using ocular vestibular evoked myogenic potential (oVEMP), cervical vestibular evoked myogenic potential (cVEMP), caloric tests, video Head Impulse Tests (vHIT), and Suppression Head Impulse Paradigm (SHIMP) tests. METHODS Twenty-two patients with AN (study group) and 50 age-and-gender-matched healthy subjects (control group) were enrolled. All patients underwent air-conducted sound oVEMP and cVEMP tests. In the study group, 20 patients underwent a caloric test, 10 patients underwent a video Head Impulse Test (vHIT), and nine patients underwent the Suppression Head Impulse Paradigm (SHIMP) test. RESULTS Significant differences in VEMP abnormalities were found between the two groups. Most AN patients showed no VEMP response, while only a few patients showed VEMP responses with normal parameters. Some AN patients presented abnormal VEMP parameters, including thresholds, latencies, and amplitudes. The abnormal rate (including no response and abnormal parameters) was 91% in the cVEMP test and 86% in the oVEMP test. No significant difference was found between oVEMP and cVEMP abnormalities. AN patients exhibited a 70% abnormal rate in the caloric test. Most AN patients showed normal VOR gains. Most patients showed no overt corrective saccades in vHIT, and exhibited normal anticompensatory saccades in the SHIMP test. CONCLUSION Many AN patients experience vestibular dysfunction, which may be detected by using a vestibular functional test battery. SIGNIFICANCE VEMP abnormalities might reflect the status and degree of vestibular involvement in AN.

中文翻译：

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前庭诱发肌源性电位检测听神经病患者的前庭功能障碍

目的 本研究旨在使用眼前庭诱发肌源性电位 (oVEMP)、颈前庭诱发肌源性电位 (cVEMP)、热量测试、视频头部脉冲测试 (vHIT) 和抑制性头部脉冲来确定听神经病 (AN) 患者的前庭受累情况范式 (SHIMP) 测试。方法 22 例 AN 患者（研究组）和 50 例年龄和性别匹配的健康受试者（对照组）被纳入。所有患者均接受了空气传导声 oVEMP 和 cVEMP 测试。在研究组中，20 名患者接受了热量测试，10 名患者接受了视频头部脉冲测试 (vHIT)，9 名患者接受了抑制性头部脉冲模式 (SHIMP) 测试。结果 两组之间 VEMP 异常存在显着差异。大多数 AN 患者没有表现出 VEMP 反应，而只有少数患者表现出正常参数的 VEMP 反应。一些 AN 患者呈现异常 VEMP 参数，包括阈值、潜伏期和幅度。异常率（包括无反应和异常参数）在 cVEMP 测试中为 91%，在 oVEMP 测试中为 86%。oVEMP 和 cVEMP 异常之间没有发现显着差异。AN 患者在热量测试中表现出 70% 的异常率。大多数 AN 患者表现出正常的 VOR 增益。大多数患者在 vHIT 中没有表现出明显的矫正性扫视，而在 SHIMP 测试中表现出正常的抗代偿性扫视。结论 许多 AN 患者会出现前庭功能障碍，这可以通过使用前庭功能测试电池来检测。意义 VEMP 异常可能反映 AN 中前庭受累的状态和程度。