Abdominal aortic aneurysms (AAAs) are highly lethal cardiovascular diseases without effective medications. However, the molecular and signaling mechanisms remain unclear. A series of pathological cellular processes have been shown to contribute to AAA formation, including vascular extracellular matrix remodeling, inflammatory and immune responses, oxidative stress, and dysfunction of vascular smooth muscle cells. Each cellular process involves complex cellular signaling, such as NF-κB, MAPK, TGFβ, Notch and inflammasome signaling. In this review, we discuss how cellular signaling networks function in various cellular processes during the pathogenesis and progression of AAA. Understanding the interaction of cellular signaling networks with AAA pathogenesis as well as the crosstalk of different signaling pathways is essential for the development of novel therapeutic approaches to and personalized treatments of AAA diseases.

中文翻译：

---

腹主动脉瘤中的细胞信号传导。

腹主动脉瘤 (AAA) 是一种高度致命的心血管疾病，没有有效的药物治疗。然而，分子和信号传导机制仍不清楚。一系列病理细胞过程已被证明有助于 AAA 的形成，包括血管细胞外基质重塑、炎症和免疫反应、氧化应激和血管平滑肌细胞功能障碍。每个细胞过程都涉及复杂的细胞信号，如 NF-κB、MAPK、TGFβ、Notch 和炎症小体信号。在这篇综述中，我们讨论了细胞信号网络在 AAA 的发病机制和进展过程中如何在各种细胞过程中发挥作用。