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Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients.
Clinica Chimica Acta ( IF 3.2 ) Pub Date : 2020-02-15 , DOI: 10.1016/j.cca.2020.02.014
Yao-Chang Liu , Jen-Pi Tsai , Li-Hsuan Wang , Ming-Che Lee , Bang-Gee Hsu

BACKGROUND Fibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients. METHODS The fasting blood samples of RT recipients (n = 66) were collected and analyzed. RESULTS A total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a higher prevalence of diabetes (P < 0.001), hypertension (P = 0.001), and metabolic syndrome (P = 0.023); longer post-RT duration (P = 0.006); higher systolic blood pressure (P < 0.001) and diastolic blood pressure (P = 0.024); and higher fasting glucose (P = 0.002), total cholesterol (P = 0.049), blood urea nitrogen (P = 0.027), phosphorus (P = 0.047), and FGF-23 concentrations (P = 0.003) and FGF-23/α-klotho ratio (P < 0.001) but lower klotho concentrations (P = 0.025) than those in the control group. Moreover, FGF-23 concentration (adjusted odds ratio: 1.057, 95% confidence interval: 1.011-1.105, P = 0.015) was found to be an independent predictor of peripheral AS in RT recipients. CONCLUSIONS Serum FGF-23 concentration was a significant predictor of peripheral AS in RT recipients.

中文翻译:

肾移植患者血清成纤维细胞生长因子23与周围动脉僵硬度正相关。

背景技术成纤维细胞生长因子23(FGF-23)除了调节矿物质代谢外,还具有动脉硬度(AS)的作用。我们调查了肾移植(RT)受体中FGF-23浓度与周围AS的关系。方法收集并分析RT接受者的空腹血液样本(n = 66)。结果共有29名(43.9%)RT接受者被归类为外周AS组。该组的RT接受者具有较高的糖尿病(P <0.001),高血压(P = 0.001)和代谢综合征(P = 0.023)的患病率;放疗后持续时间更长(P = 0.006);较高的收缩压(P <0.001)和舒张压(P = 0.024); 和更高的空腹血糖(P = 0.002),总胆固醇(P = 0.049),血尿素氮(P = 0.027),磷(P = 0.047),FGF-23浓度(P = 0.003)和FGF-23 /α-klotho比(P <0.001),但klotho浓度(P = 0.025)低于对照组。此外,发现FGF-23浓度(调整比值比:1.057,95%置信区间:1.011-1.105,P = 0.015)是RT受体周围性AS的独立预测因子。结论血清FGF-23浓度是RT受体周围AS的重要预测指标。
更新日期:2020-02-20
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