BACKGROUND Fibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients. METHODS The fasting blood samples of RT recipients (n = 66) were collected and analyzed. RESULTS A total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a higher prevalence of diabetes (P < 0.001), hypertension (P = 0.001), and metabolic syndrome (P = 0.023); longer post-RT duration (P = 0.006); higher systolic blood pressure (P < 0.001) and diastolic blood pressure (P = 0.024); and higher fasting glucose (P = 0.002), total cholesterol (P = 0.049), blood urea nitrogen (P = 0.027), phosphorus (P = 0.047), and FGF-23 concentrations (P = 0.003) and FGF-23/α-klotho ratio (P < 0.001) but lower klotho concentrations (P = 0.025) than those in the control group. Moreover, FGF-23 concentration (adjusted odds ratio: 1.057, 95% confidence interval: 1.011-1.105, P = 0.015) was found to be an independent predictor of peripheral AS in RT recipients. CONCLUSIONS Serum FGF-23 concentration was a significant predictor of peripheral AS in RT recipients.

中文翻译：

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肾移植患者血清成纤维细胞生长因子23与周围动脉僵硬度正相关。

背景技术成纤维细胞生长因子23（FGF-23）除了调节矿物质代谢外，还具有动脉硬度（AS）的作用。我们调查了肾移植（RT）受体中FGF-23浓度与周围AS的关系。方法收集并分析RT接受者的空腹血液样本（n = 66）。结果共有29名（43.9％）RT接受者被归类为外周AS组。该组的RT接受者具有较高的糖尿病（P <0.001），高血压（P = 0.001）和代谢综合征（P = 0.023）的患病率；放疗后持续时间更长（P = 0.006）；较高的收缩压（P <0.001）和舒张压（P = 0.024）; 和更高的空腹血糖（P = 0.002），总胆固醇（P = 0.049），血尿素氮（P = 0.027），磷（P = 0.047），FGF-23浓度（P = 0.003）和FGF-23 /α-klotho比（P <0.001），但klotho浓度（P = 0.025）低于对照组。此外，发现FGF-23浓度（调整比值比：1.057，95％置信区间：1.011-1.105，P = 0.015）是RT受体周围性AS的独立预测因子。结论血清FGF-23浓度是RT受体周围AS的重要预测指标。