We propose a novel stimulated emission depletion (STED) microscopy based on array detection and photon reassignment. By replacing the single-point detector in traditional STED with a detector array and utilizing the photon reassignment method to recombine the images acquired by each detector, the final photon reassignment STED (prSTED) image could be obtained. We analyze the principle and imaging characteristics of prSTED, and the results indicate that, compared with traditional STED, prSTED can improve the signal-to-noise ratio (SNR) of the image by increasing the obtained photon flux while maintaining the original spatial resolution of STED. In addition, the SNR and resolution of prSTED are strongly correlated with the intensity of depletion beam. Corresponding theoretical and experimental analysis about this feature are also conducted. In general, considering the enhanced signal strength, imaging speed and compatibility with some other imaging techniques, we believe prSTED would be a helpful promotion in biomedical imaging.

中文翻译：

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具有阵列检测和光子重新分配的受激发射耗尽显微镜

我们提出了一种基于阵列检测和光子重新分配的新型受激发射耗尽 (STED) 显微镜。通过用探测器阵列代替传统STED中的单点探测器，并利用光子重新分配方法重新组合每个探测器获取的图像，可以获得最终的光子重新分配STED（prSTED）图像。我们分析了 prSTED 的原理和成像特性，结果表明，与传统 STED 相比，prSTED 在保持原始空间分辨率的同时，通过增加获得的光子通量来提高图像的信噪比（SNR）。斯特德。此外，prSTED 的 SNR 和分辨率与耗尽光束的强度密切相关。还对该特性进行了相应的理论和实验分析。