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Sleep disorders in cystic fibrosis: A systematic review and meta-analysis.
Sleep Medicine Reviews ( IF 11.2 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.smrv.2020.101279
Joel Reiter 1 , Alex Gileles-Hillel 1 , Malena Cohen-Cymberknoh 1 , Dennis Rosen 2 , Eitan Kerem 1 , David Gozal 3 , Erick Forno 4
Affiliation  

Cystic fibrosis (CF) is a genetic disorder that leads to airway mucus accumulation, chronic inflammation, and recurrent respiratory infections – all likely impacting sleep. However, controlled studies of sleep in CF patients are limited, and have shown mixed results. We reviewed all publications on CF and sleep indexed in PubMed, CINAHL, and Scopus through April 2019. In the meta-analysis, we calculated pooled weighted mean differences for sleep quality, sleepiness, oximetry, and polysomnographic (PSG) parameters, using fixed or random-effects models as appropriate. A total of 87 manuscripts were reviewed. Compared to controls, children with CF had lower nighttime oxygen saturation nadirs, decreased sleep efficiency and a higher respiratory event index, with no differences in the percentage of REM sleep. Adults with CF had lower oxygen saturation nadirs, with a trend towards reduced sleep efficiency and no differences in REM sleep. In addition, patients with CF cough more during sleep and experience painful events that interfere with sleep. Actigraphy and questionnaires suggest disturbed sleep and daytime sleepiness. Noninvasive ventilation appears to improve gas exchange and symptoms.

We conclude that when sleep is evaluated objectively or subjectively in patients with CF, perturbations are common, emphasizing the importance of their identification and treatment and inclusion as part of routine care. Additional research, with larger sample sizes and standardized outcomes, are necessary.



中文翻译:

囊性纤维化的睡眠障碍:系统评价和荟萃分析。

囊性纤维化(CF)是一种遗传性疾病,可导致气道粘液积聚,慢性炎症和反复呼吸道感染-所有这些都可能影响睡眠。但是,对CF患者的睡眠进行的对照研究非常有限,并且结果不一。我们审查了截至2019年4月在PubMed,CINAHL和Scopus上索引的CF和睡眠的所有出版物。在荟萃分析中,我们使用固定值或固定值计算了睡眠质量,嗜睡,血氧饱和度和多导睡眠图(PSG)参数的合并加权平均差。适当的随机效应模型。共审查了87篇手稿。与对照组相比,患有CF的儿童夜间氧饱和度最低点更低,睡眠效率降低,呼吸事件指数更高,REM睡眠百分比没有差异。患有CF的成年人的氧饱和度最低点较低,有降低睡眠效率的趋势,REM睡眠无差异。此外,CF患者在睡眠中会咳嗽得更多,并且会经历痛苦的​​事件来干扰睡眠。书法和问卷表明睡眠和白天嗜睡受到干扰。无创通气似乎可以改善气体交换和症状。

我们得出的结论是,在CF患者中客观或主观地评估睡眠时,摄动很常见,强调了对其进行识别和治疗以及将其纳入常规护理的重要性。需要进行更大样本量和标准化结果的附加研究。

更新日期:2020-02-19
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