Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I.

中文翻译：

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二甲双胍对线粒体复合物 I 的抑制作用：药物-运动相互作用

二甲双胍具有抗糖尿病、抗癌和延长寿命的作用，但似乎会干扰有氧训练线粒体适应性。已提出主要作用机制是抑制线粒体复合物 I。 然而，最近的论文（Wang 等人和 Cameron 等人）提供证据否认二甲双胍对复合物 I 有直接作用的假设。