Phagocytosis of apoptotic cells via the receptor MerTK is important for immune tolerance. In this issue of Immunity, Zhou et al. report that blockade of MerTK-mediated phagocytosis mobilizes anti-tumor immunity through a mechanism that involves the transport of tumor-derived cGAMP into macrophages via the ATP-activated channel P2X7R.

中文翻译：

---

MerTK封锁增强了抗肿瘤免疫力。

通过受体MerTK进行的凋亡细胞吞噬作用对于免疫耐受很重要。在本期《免疫》中，Zhou等人。报告指出，MerTK介导的吞噬作用的阻断通过一种机制将抗肿瘤免疫力调动起来，该机制涉及将肿瘤来源的cGAMP通过ATP激活的通道P2X7R转运至巨噬细胞。