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Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage.
Immunity ( IF 25.5 ) Pub Date : 2020-02-18 , DOI: 10.1016/j.immuni.2020.01.008 Xiaoxue Li 1 , Samuel Rommelaere 1 , Shu Kondo 2 , Bruno Lemaitre 1
Immunity ( IF 25.5 ) Pub Date : 2020-02-18 , DOI: 10.1016/j.immuni.2020.01.008 Xiaoxue Li 1 , Samuel Rommelaere 1 , Shu Kondo 2 , Bruno Lemaitre 1
Affiliation
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Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules, the insect kidney. This lipid purge was mediated by a stress-induced lipid-binding protein, Materazzi, which was enriched in Malpighian tubules. Flies lacking materazzi had higher hemolymph concentrations of reactive oxygen species (ROS) and increased lipid peroxidation. These flies also displayed Malpighian tubule dysfunction and were susceptible to infections and environmental stress. Feeding flies with antioxidants rescued the materazzi phenotype, indicating that the main role of Materazzi is to protect the organism from damage caused by stress-induced ROS. Our findings suggest that purging hemolymphatic lipids presents a physiological adaptation to protect host tissues from excessive ROS during immune and stress responses, a process that is likely to apply to other organisms.
中文翻译：
肾冲洗血淋巴脂质可防止ROS诱导的炎性氧化脂质蓄积，并保护果蝇免受组织损伤。
动物需要复杂的代谢和生理适应才能维持重要器官的功能，以应对环境压力和感染。在这里，我们发现果蝇的感染或伤害会导致Malpighian小管（昆虫肾脏）排泄淋巴脂质。这种脂质清除是由应激诱导的脂质结合蛋白Materazzi介导的，该蛋白富含Malpighian小管。缺乏materazzi的蝇具有较高的活性氧血氧浓度（ROS）和脂质过氧化作用增加。这些苍蝇还表现出马尔皮基小管功能障碍，容易感染和环境压力。用抗氧化剂喂养果蝇可以挽救马特拉齐的表型，这表明马塔拉齐的主要作用是保护有机体免受压力引起的活性氧引起的损害。
更新日期：2020-02-20
中文翻译：
肾冲洗血淋巴脂质可防止ROS诱导的炎性氧化脂质蓄积，并保护果蝇免受组织损伤。
动物需要复杂的代谢和生理适应才能维持重要器官的功能，以应对环境压力和感染。在这里，我们发现果蝇的感染或伤害会导致Malpighian小管（昆虫肾脏）排泄淋巴脂质。这种脂质清除是由应激诱导的脂质结合蛋白Materazzi介导的，该蛋白富含Malpighian小管。缺乏materazzi的蝇具有较高的活性氧血氧浓度（ROS）和脂质过氧化作用增加。这些苍蝇还表现出马尔皮基小管功能障碍，容易感染和环境压力。用抗氧化剂喂养果蝇可以挽救马特拉齐的表型，这表明马塔拉齐的主要作用是保护有机体免受压力引起的活性氧引起的损害。
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