Cellular identity is not driven by differences in genomic content but rather by epigenomic, transcriptomic, and proteomic heterogeneity. Although regulation of the epigenome plays a key role in shaping stem cell hierarchies, differential expression of transcripts only partially explains protein abundance. The epitranscriptome, translational control, and protein degradation have emerged as fundamental regulators of proteome complexity that regulate stem cell identity and function. Here, we discuss how post-transcriptional mechanisms enable stem cell homeostasis and responsiveness to developmental cues and environmental stressors by rapidly shaping the content of their proteome and how these processes are disrupted in pre-malignant and malignant states.

中文翻译：

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稳态、应激和恶性干细胞的转录后调节。


细胞同一性不是由基因组内容的差异驱动的，而是由表观基因组、转录组和蛋白质组异质性驱动的。尽管表观基因组的调控在塑造干细胞层次结构中发挥着关键作用，但转录本的差异表达只能部分解释蛋白质丰度。表观转录组、翻译控制和蛋白质降解已成为调节干细胞身份和功能的蛋白质组复杂性的基本调节因子。在这里，我们讨论转录后机制如何通过快速塑造其蛋白质组的内容来实现干细胞稳态和对发育线索和环境压力源的反应，以及这些过程如何在癌前和恶性状态下被破坏。