For decades, scientists have observed small extrachromosomal DNA fragments in tumor cells, yet comprehensive examination of their structure and function has remained difficult. Three recent studies, published in Nature, Cell, and Nature Genetics, have now shed important light on the architecture, regulatory capacity, and oncogenic nature of tumor-associated extrachromosomal DNA.

中文翻译：

---

有一个圆圈：致癌染色体外DNA的新见解。

几十年来，科学家一直在肿瘤细胞中观察到染色体外的小DNA片段，但是对其结构和功能进行全面检查仍然很困难。最近发表在《自然》，《细胞》和《自然遗传学》上的三项研究，为与肿瘤相关的染色体外DNA的结构，调控能力和致癌性提供了重要启示。