In a recent iScience paper by Fan et al., the long noncoding (lnc)RNA CISAL is shown to form a DNA–RNA triplex and to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as a treatment efficacy biomarker. This opens promising avenues of research from both mechanistic and translational perspectives.

中文翻译：

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lncRNA诱饵可预测对顺铂的敏感性

在Fan等人的最新iScience论文中。，长的非编码（lnc）RNA CISAL被证明可形成DNA-RNA三链体并直接调节BRCA1转录，从而提高顺铂敏感性，并作为治疗功效的生物标志物。这从机械和翻译的角度开辟了有希望的研究途径。