Increasing evidence of interdependence between G protein-coupled receptors and receptor tyrosine kinase signaling pathways has prompted reevaluation of crosstalk between these receptors in disease and therapy. Investigations into thyroid-stimulating hormone (TSH) and insulin-like growth factor 1 (IGF1) receptor crosstalk, and its application to the clinic have in particular shown recent progress. In this review, we summarize current insights into the mechanism of TSH/IGF1 receptor crosstalk. We discuss evidence that crosstalk is one of the underlying causes of TSHR-based disease and the feasibility of using combinations of TSH receptor and IGF1 receptor antagonists to increase the therapeutic index for the treatment of Graves' hyperthyroidism and Graves' ophthalmopathy.

中文翻译：

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TSH / IGF1受体串扰：机制和临床意义。

G蛋白偶联受体与酪氨酸激酶信号通路之间相互依赖的证据越来越多，这促使人们重新评估疾病和治疗中这些受体之间的串扰。对甲状腺刺激激素（TSH）和胰岛素样生长因子1（IGF1）受体串扰的研究及其在临床中的应用特别表明了最近的进展。在这篇综述中，我们总结了对TSH / IGF1受体串扰机制的最新见解。我们讨论了串扰是基于TSHR的疾病的根本原因之一的证据，以及使用TSH受体和IGF1受体拮抗剂组合以提高Graves甲状腺功能亢进和Graves眼病治疗指数的可行性。