Enhancer of Zeste Homolog 2 (EZH2) is highly expressed in kinds of malignant tumors and related to tumor occurrence, development, and prognosis. EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which promotes cell proliferation, migration, and invasion by epigenetic regulation of anti-tumor gene. It can activate numerous tumor-associated signaling pathways and interfere with DNA damage repair. In recent years, large amounts of studies have shown that EZH2 is closely related to gynecologic-related malignancies and can be used as a potential target gene for the treatment of gynecological-related malignancies. This review summarizes the oncogenic function of EZH2 and introduces the recent advances in the development of EZH2 inhibitors. On this basis, future research prospect of EZH2 is proposed.

中文翻译：

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EZH2在妇科癌症中的致癌作用和治疗作用。

Zeste Homolog 2（EZH2）的增强子在各种恶性肿瘤中高表达，并且与肿瘤的发生，发展和预后相关。EZH2是多梳抑制复合物2（PRC2）的催化亚基，通过表观遗传调控抗肿瘤基因来促进细胞增殖，迁移和侵袭。它可以激活许多与肿瘤相关的信号通路，并干扰DNA损伤修复。近年来，大量研究表明，EZH2与妇科相关恶性肿瘤密切相关，可作为治疗妇科相关恶性肿瘤的潜在靶基因。这篇综述总结了EZH2的致癌作用，并介绍了EZH2抑制剂开发的最新进展。在此基础上，提出了EZH2的未来研究前景。