当前位置：
X-MOL 学术
›
Biosens. Bioelectron.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Flexible and self-healing electrochemical hydrogel sensor with high efficiency toward glucose monitoring.
Biosensors and Bioelectronics ( IF 10.7 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.bios.2020.112105 Zhen Liang 1 , Jieyu Zhang 1 , Can Wu 1 , Xuefeng Hu 1 , Yuhui Lu 1 , Guangfeng Wang 2 , Fei Yu 3 , Xiaojun Zhang 2 , Yunbing Wang 1
Biosensors and Bioelectronics ( IF 10.7 ) Pub Date : 2020-02-19 , DOI: 10.1016/j.bios.2020.112105 Zhen Liang 1 , Jieyu Zhang 1 , Can Wu 1 , Xuefeng Hu 1 , Yuhui Lu 1 , Guangfeng Wang 2 , Fei Yu 3 , Xiaojun Zhang 2 , Yunbing Wang 1
Affiliation
|
The commercial sensor of a continuous glucose monitoring system suffers from restricted penetration of glucose in the dense sensing coating, uncontrolled leakage of the glucose oxidase and electrocatalytic medium, and susceptibility to mechanical damage. Herein, a self-healing hydrogel based on quaternized chitosan and oxidized dextran was designed, and CeO2/MnO2 hollow nanospheres were covalently linked in the hydrogel as the electrocatalytic medium. Glucose oxidase was loaded via the strong electrostatic interactions with the CeO2/MnO2 hollow nanospheres. An extra covering agent was coated on the hydrogel to prevent the leakage of the glucose oxidase and electrocatalytic medium. Covalent linkage of the hydrogel on a bendable chip formed a flexible glucose sensor, which showed a wide linear range (1-111 mM), fast response (less than 3 s), and high sensitivity (176 μA mM-1 cm-2). The hydrogel-based sensor was self-healable, and could continuously work for over 30 days. Thus, this study provides a method to simultaneously prevent the leakage of the electrocatalytic medium, promote the sensitivity of glucose detection, and tolerate the mechanical damage, which shows great potential for continuous glucose monitoring.
中文翻译：
灵活，自我修复的电化学水凝胶传感器，对葡萄糖的监测效率很高。
连续葡萄糖监测系统的商业传感器遭受葡萄糖在致密传感涂层中的渗透受限，葡萄糖氧化酶和电催化介质的失控泄漏以及对机械损伤的敏感性。本文设计了一种基于季铵化壳聚糖和氧化葡聚糖的自修复水凝胶，并将CeO2 / MnO2中空纳米球在水凝胶中作为电催化介质共价连接。葡萄糖氧化酶通过与CeO2 / MnO2中空纳米球的强静电相互作用而装载。将额外的覆盖剂涂覆在水凝胶上，以防止葡萄糖氧化酶和电催化介质的泄漏。水凝胶在可弯曲芯片上的共价键形成了一个柔性葡萄糖传感器，该传感器显示出宽线性范围（1-111 mM），快速响应（小于3 s），和高灵敏度（176μAmM-1 cm-2）。基于水凝胶的传感器具有自我修复功能，可以连续工作30天以上。因此，本研究提供了一种同时防止电催化介质泄漏，提高葡萄糖检测灵敏度和耐受机械损伤的方法，这显示出进行连续葡萄糖监测的巨大潜力。
更新日期：2020-02-20
中文翻译：
灵活，自我修复的电化学水凝胶传感器，对葡萄糖的监测效率很高。
连续葡萄糖监测系统的商业传感器遭受葡萄糖在致密传感涂层中的渗透受限，葡萄糖氧化酶和电催化介质的失控泄漏以及对机械损伤的敏感性。本文设计了一种基于季铵化壳聚糖和氧化葡聚糖的自修复水凝胶，并将CeO2 / MnO2中空纳米球在水凝胶中作为电催化介质共价连接。葡萄糖氧化酶通过与CeO2 / MnO2中空纳米球的强静电相互作用而装载。将额外的覆盖剂涂覆在水凝胶上，以防止葡萄糖氧化酶和电催化介质的泄漏。水凝胶在可弯曲芯片上的共价键形成了一个柔性葡萄糖传感器，该传感器显示出宽线性范围（1-111 mM），快速响应（小于3 s），和高灵敏度（176μAmM-1 cm-2）。基于水凝胶的传感器具有自我修复功能，可以连续工作30天以上。因此，本研究提供了一种同时防止电催化介质泄漏，提高葡萄糖检测灵敏度和耐受机械损伤的方法，这显示出进行连续葡萄糖监测的巨大潜力。
京公网安备 11010802027423号