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Connectome‐based propagation model in amyotrophic lateral sclerosis
Annals of Neurology ( IF 8.1 ) Pub Date : 2020-03-11 , DOI: 10.1002/ana.25706
Jil M Meier 1 , Hannelore K van der Burgh 1 , Abram D Nitert 1 , Peter Bede 2, 3, 4 , Siemon C de Lange 5 , Orla Hardiman 6, 7 , Leonard H van den Berg 1 , Martijn P van den Heuvel 5, 8
Affiliation  

Clinical trials in amyotrophic lateral sclerosis (ALS) continue to rely on survival or functional scales as endpoints, despite the emergence of quantitative biomarkers. Neuroimaging‐based biomarkers in ALS have been shown to detect ALS‐associated pathology in vivo, although anatomical patterns of disease spread are poorly characterized. The objective of this study is to simulate disease propagation using network analyses of cerebral magnetic resonance imaging (MRI) data to predict disease progression.

中文翻译:


肌萎缩侧索硬化症中基于连接体的传播模型



尽管出现了定量生物标志物,但肌萎缩侧索硬化症 (ALS) 的临床试验仍然依赖生存或功能量表作为终点。尽管疾病传播的解剖模式尚不清楚,但 ALS 中基于神经影像的生物标志物已被证明可以在体内检测 ALS 相关病理。本研究的目的是使用脑磁共振成像 (MRI) 数据的网络分析来模拟疾病传播,以预测疾病进展。
更新日期:2020-03-11
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