Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-02-19 , DOI: 10.1038/s41372-020-0606-4 I Chervoneva 1 , S C Adeniyi-Jones 1, 2 , F Blanco 1 , W K Kraft 1
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Objective
We sought a shortened MOTHER neonatal abstinence syndrome (NAS) and Finnegan score that would retain comparable performance characteristics of the full instrument.
Study design
Retrospective cohort.
Results
In total, 124,170 MOTHER NAS scores between August 2007 and May 2016 from 775 infants (≥36 weeks) were examined. Classification and regression tree model identified the most important subsets of the scored variables. A 9-element shortened scale yielded >90% sensitivity and specificity to predict clinical endpoints based on the full 19-element MOTHER NAS score. Conversion of the data sets to the Finnegan score, and applying the same procedure resulted in a nine-element score with similar performance characteristics.
Conclusion
Shortened scoring instruments were identified with the high-predictive power for clinical endpoints based on the 19-element full MOTHER NAS score. There was no substantial variation in performance for age, supporting the current practice of utilizing a single scoring tool regardless of postnatal age.
中文翻译：
新生儿戒断综合征简化症状评分的开发
客观的
我们寻求缩短的 MOTHER 新生儿戒断综合征 (NAS) 和 Finnegan 评分，以保留完整仪器的可比性能特征。
学习规划
回顾性队列。
结果
总共检查了 2007 年 8 月至 2016 年 5 月期间来自 775 名婴儿（≥36 周）的 124,170 份 MOTHER NAS 评分。分类和回归树模型确定了评分变量的最重要子集。基于完整的 19 元素 MOTHER NAS 评分，9 元素缩短量表产生 >90% 的敏感性和特异性来预测临床终点。将数据集转换为 Finnegan 评分，并应用相同的程序，得到具有相似性能特征的九要素评分。
结论
基于 19 个元素的完整 MOTHER NAS 评分，缩短的评分工具对临床终点具有高预测能力。年龄的表现没有显着差异，支持当前使用单一评分工具的做法，无论出生后年龄如何。
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