We have developed a dual-sensitive composite hydrogel network from guar gum grafted polyacrylamidoglycolic acid (graft polymer) using sodium borohydride, which induces cross-linking and growth of silver nuclei by reduction reaction through a fast and easy route. The cross-linked graft polymer (GGAA) and its silver nanocomposite (GGAA@SNC) hydrogels have been successfully utilized to explore sustained release of 5-fluorouracil (5-FU), an anticancer drug, and antibacterial activity was evaluated. The composite hydrogels exhibit sol-gel behavior due to pH and temperature effect. To identify the functional interactions of pure guar gum (GG), graft polymer, 5-FU loaded GGAA and GGAA@SNC hydrogels, the synthesized materials are characterized by FTIR, DSC, and XRD analysis. In addition, the growth of silver nanoparticles (SNPs), its size, and stability in the hydrogel network were verified by UV-vis spectra, FE-TEM, and TGA-DTA analysis. Additionally, the structural morphology and porosity of polymer structures were observed by FE-SEM analysis. The different polymer network parameters (Mc, χ, 휉 and ϕ) and diffusion constant (D) were calculated by using swelling data and evaluated to assess the drug release profile. The diffusion exponents (n) were determined by studying 5-FU release behavior of the composite hydrogels in phosphate buffer solution (pH = 1.2 & 7.4); in vitro release data indicated that, maximum 5-FU release was significantly achieved in pH 7.4 rather than pH 1.2. The GGAA@SNC hydrogels showed excellent antibacterial activity towards Bacillus subtilis and Salmonella ebony using zone of inhibition test. A versatile strategy has been developed to prepare GGAA@SNC hydrogels to enhance 5-FU release over 16 h for its effective anticancer drug release applications.

我们已经开发了一种使用硼氢化钠的瓜尔豆胶接枝的聚丙烯酰胺基乙醇酸（接枝聚合物）制成的双敏感复合水凝胶网络，该网络通过快速简便的还原反应诱导银核的交联和生长。交联的接枝聚合物（GGAA）及其银纳米复合材料（GGAA @ SNC）水凝胶已成功用于探索抗癌药物5-氟尿嘧啶（5-FU）的持续释放，并评估了其抗菌活性。由于pH和温度效应，复合水凝胶表现出溶胶-凝胶行为。为了鉴定纯瓜尔胶（GG），接枝聚合物，5-FU负载的GGAA和GGAA @ SNC水凝胶的功能相互作用，通过FTIR，DSC和XRD分析对合成的材料进行了表征。此外，银纳米颗粒（SNP）的生长，大小，通过紫外可见光谱，FE-TEM和TGA-DTA分析验证了水凝胶网络的稳定性和稳定性。另外，通过FE-SEM分析观察了聚合物结构的结构形态和孔隙率。不同的聚合物网络参数（Mc，χ，휉和sw）和扩散常数（D）通过使用溶胀数据进行计算，并进行评估以评估药物释放曲线。通过研究复合水凝胶在磷酸盐缓冲溶液（pH = 1.2和7.4）中的5-FU释放行为来确定扩散指数（n）；体外释放数据表明，在pH 7.4而不是pH 1.2时，最大的5-FU释放达到最大。GGAA @ SNC水凝胶通过抑制区试验显示出对枯草芽孢杆菌和沙门氏菌乌木具有优异的抗菌活性。已经开发了一种通用策略来制备GGAA @ SNC水凝胶，以在有效的抗癌药物释放应用中在16小时内增强5-FU的释放。