Downstream purification of products and intermediates is essential for the development of continuous flow processes. Described herein, is a study on the use of a modular and reconfigurable continuous flow platform for the self-optimisation of reactive extractions and multi-step reaction-extraction processes. The selective extraction of one amine from a mixture of two similar amines was achieved with an optimum separation of 90%, and in this case, the black-box optimisation approach was superior to global polynomial modelling. Furthermore, this methodology was utilised to simultaneously optimise the continuous flow synthesis and work-up of N-benzyl-α-methylbenzylamine with respect to four variables, resulting in a significantly improved purity.

产品和中间体的下游纯化对于开发连续流程至关重要。本文描述了对模块化和可重构连续流平台用于反应萃取和多步反应萃取过程的自优化的研究。从两种相似的胺的混合物中选择性提取一种胺，最佳分离率为90％，在这种情况下，黑盒优化方法优于全局多项式建模。此外，就四个变量而言，该方法被用于同时优化连续流合成和N-苄基-α-甲基苄基胺的后处理，从而显着提高了纯度。